Complicated film, almost at an Inception level. Six parallel stories, spanning five centuries from the past into the future, narrating the interactions of character pairs (lawyer/slave, music grandmaster/pupil, reporter/nuclear scientist, writer/lost lover, rebel/robot, tribal native/high-tech futurist), mostly sharing a birthmark, and all representing different reincarnates of each other - suggesting how actions/thoughts transcend through generations. The Wachowskis continue their Matrix and V for Vendetta warnings about an evil domineering global power, with a touch of Soylent Green (1973). Writing and editing must've been hell, but not sure whether such a complicated story-telling style was needed to get the message through.
PS: Almost all major actors (Hanks, Berry, Grant, Broadbent, Weaving, Sturgess, Bae) play up to six roles here, one in each story. Expect an Oscar for Best Make-Up, for the same reason.